Automated spatial genomics instrument.
Researchers and clinicians face critical bottlenecks in spatial biology datasets: slow manual imaging, complex workflows, and analysis burden. RKS was tasked with designing a fully automated spatial genomics instrument that seamlessly integrates sample handling, image capture, and user feedback while minimizing cognitive load in high stakes lab environments.
We embedded with lab technicians, researchers, and lab managers to observe spatial genomics workflows, from tissue prep to imaging and data post processing. Key insights centered on workflow complexity, instrument intimidation, clog points in reagent usage, and trust in analytical outcomes. Using Psycho‑Aesthetics®, we positioned the system within the artistic quadrant to balance precision with visual clarity and ease of use.
Lab workflow and persona mapping
Emotional journey insights highlighting trust and clarity
Competitive benchmark and opportunity analysis
How We Used Psycho-Aesthetics™ to Identify Unique Opportunities in the Project.
Using our proprietary Psycho-Aesthetics® 2.0 framework, we conducted in-depth interviews and ethnographic observation in diverse lab settings. We identified key emotional and usability pain points — such as intimidation with complex interfaces, workspace clutter, and trust in precision. These insights guided both the form and interface strategy, ensuring approachability and confidence in operation.
With validated insights, we shaped a modular, high throughput platform designed for real world spatial genomics use. Our innovation strategy emphasized automation, scalable sample architecture, and intuitive maintenance, enabling rapid ROI for research institutions.
Modular system architecture that optimizes sample loading and sequencing cycles
Workflow innovation roadmap addressing throughput, customization, and future expansion
Materials and CMF strategy aligned with sterile lab environments and data-forward branding
Form and experience were combined into an ergonomic tower chassis featuring front side consumable access and status lighting. The touchscreen interface offers guided workflows that reduce navigation errors and provide clear feedback, simplifying operation in high volume lab settings.
CAD renderings for optimized bench footprint and front access design
Touchscreen interface layout with custom iconography and task flows
CMF treatments supporting lab grade durability and brand coherence
We engineered fluidics integration, modular reagent handling, and precision optics to support highly accurate spatial sequencing. Iterative prototyping and validation ensured reliability across thermal, environmental, and connectivity demands.
Functional engineering builds validated for workflow reliability
Mechanical and CAD/CAM deliverables optimized for manufacturability
Performance testing across fluidics, temperature control, and alignment precision
The Spatial Genomics platform exemplifies RKS Design’s mastery in elevating highly technical life science equipment into accessible, elegant, and ergonomic tools. By combining strategic innovation consulting, emotionally intelligent branding, and engineering rigor, we accelerated breakthrough spatial biology adoption, empowering scientists with next generation capabilities in precision medicine and discovery driven research.
Status: Fully designed and prototyped; platform is operational and scaling in genomics labs globally
Market Impact:
Enabled automated spatial imaging experiments in oncology, immunology, and diagnostics
Integrated G4X expansion platform broadens applications across spatial multiomics
Serves as a high performance instrument in clinical and research workflows
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